Methodology

Our credibility rests on being honest about how strong the evidence really is. Most peptides in this space are sold on the back of animal data or mechanism alone. We grade that plainly so you can tell the difference between “proven in humans” and “promising in a petri dish.”

Our evidence grades

Every profile carries one of five grades, strongest to weakest:

• E1Human RCTRandomized controlled trials in humans — the strongest evidence we grade.
• E2Human (observational)Human data from non-randomized studies: cohorts, case series, case reports.
• E3AnimalPreclinical evidence from animal models only — not yet shown in humans.
• E4In vitroCell- or tissue-culture evidence only — far from clinical proof.
• E5TheoreticalMechanistically plausible but not yet demonstrated in any living system.

How we source claims

• We work from primary literature — PubMed-indexed studies — and paraphrase findings in our own words. We never copy abstracts.
• Each cited study gets a one-sentence, plain-English summary and a link to the source so you can check our reading.
• We state evidence ceilings explicitly. “No published human RCTs” is the headline, not a footnote, when that is the truth.
• Every profile carries a visible “last updated” date, and the study tracker shows our citations newest-first.

How we vet vendors

Our “where to buy” pages list vendors against objective signals — third-party testing, certificate-of-analysis availability, and shipping — rather than hype. Any future commercial relationship is disclosed and never changes a grade or a vetting decision.

What we are not

We are not a medical provider and this is not medical advice. The compounds we cover are discussed for research purposes only. See our full disclaimer.