TB-500

TB-500 is marketed as a synthetic form of thymosin β-4 (Tβ4), a peptide your body produces that binds and regulates actin, a core building block of the cell skeleton. By influencing actin dynamics, Tβ4 promotes cell migration, new blood-vessel formation, and reduced inflammation at injury sites in animal models. Note that much of what is sold as "TB-500" is actually a shorter fragment of Tβ4, not the full molecule used in clinical research — see our separate fragment profile.

The strongest data are for the full thymosin β-4 molecule, which has been the subject of ongoing and projected clinical trials across four areas: skin wound healing, corneal injury, cardiac repair after ischemic injury, and CNS recovery. Generic "TB-500" sold to consumers is a research chemical with little independent verification that it matches the clinically studied peptide. Animal evidence for tendon, muscle, and cardiac repair is encouraging but not a substitute for completed human efficacy trials, and long-term human safety is unestablished.

• Promoted cell migration and angiogenesis in wound-healing models
• Improved recovery in animal models of tendon, ligament, and muscle injury
• Cardioprotective and tissue-repair signals in preclinical heart-injury studies
• Early human trials of full Tβ4 for skin wounds and dry eye

• Consumer "TB-500" is often a fragment, not the clinically studied full peptide
• No completed human RCTs demonstrating the benefits people seek for injuries
• Pro-angiogenic activity is a theoretical concern in people with cancer
• Banned in sport by WADA
• Research-use-only sourcing means variable purity and dose accuracy

Research compound. Sold "for research use only" — not approved for human consumption.

Goals studied: Tendon & ligament repair, Muscle recovery

Is TB-500 the same as thymosin β-4?

Not necessarily. The clinically studied molecule is full-length thymosin β-4. Much of the "TB-500" sold to consumers is a shorter active fragment, which is why we keep a separate fragment profile.

Does TB-500 heal injuries in humans?

There are no completed human RCTs showing it heals the tendon or muscle injuries people use it for. The human-relevant evidence is early-phase and concerns the full Tβ4 molecule.

1. [1]
   Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications

   Goldstein AL, Hannappel E, Sosne G, Kleinman HK · Expert Opinion on Biological Therapy · 2012 · PMID 22074294 · model: animal

   Revue des rôles de la thymosine β4 dans la liaison à l'actine, la migration cellulaire et la réparation tissulaire, et de ses premières applications cliniques.

2. [2]
   Thymosin beta 4 promotes corneal wound healing and decreases inflammation in vivo following alkali injury

   Sosne G, Szliter EA, Barrett R, Kernacki KA, Kleinman H, Hazlett LD · Experimental Eye Research · 2002 · PMID 11950239 · model: animal

   Étude in vivo chez la souris montrant que la thymosine β4 topique accélère la ré-épithélialisation cornéenne et réduit l'inflammation après lésion.